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Article

Posttranscriptional regulation of hepatitis B virus replication by the precore protein.

Journal of virology - 1 Jan 1997

Scaglioni P P, Melegari M, Wands J R

Abstract excerpt

Hepadnaviruses encode two core-related open reading frames. One directs the synthesis of the p21 core protein, which subsequently becomes a structural component of the viral nucleocapsid. The other produces a p25 precore protein that is targeted by a signal peptide to a cell secretory pathway where N-terminal processing will create a p22 species. This molecule will be further modified at the C-terminal region to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8985356
DOI: 10.1128/JVI.71.1.345-353.1997
PMCID: PMC191057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Posttranscriptional regulation of hepatitis B virus replication by the precore protein.PMID 8985356Read ↗

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The inhibitory effect of the hepatitis B virus singly-spliced RNA-encoded p21.5 protein on HBV nucleocapsid formation.Semantic proximity Read ↗

Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame.Semantic proximity Read ↗

In Vivo Suppression of Precore mRNA Synthesis Is Associated with Mutations in the Hepatitis B Virus Core PromoterSemantic proximity Read ↗

In vitro and in vivo replication capacity of the precore region defective hepatitis B virus variants.Semantic proximity Read ↗

The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic miceSemantic proximity Read ↗

Naturally occurring hepatitis B virus mutants with deletions in the core promoter region.Semantic proximity Read ↗

Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients.Semantic proximity Read ↗

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Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replicationSemantic proximity Read ↗

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