Article
The inhibitory effect of the hepatitis B virus singly-spliced RNA-encoded p21.5 protein on HBV nucleocapsid formation.
PloS one - 1 Jan 2015
Wang Yi-Ling, Liou Gan-Guang, Lin Chao-Hsiung, Chen Mong-Liang, Kuo Tzer-Min, Tsai Kuen-Nan, Huang Chien-Choao, Chen Ya-Ling, Huang Li-Rung, Chou Yu-Chi, Chang Chungming
Abstract excerpt
Hepatitis B virus (HBV) is the smallest DNA virus and the major cause of acute and chronic hepatitis. The 3.2 kb HBV viral genome generates four major species of unspliced viral transcript as well as several alternatively spliced RNAs. A 2.2 kb singly-spliced RNA is the most abundant spliced RNA and is widely expressed among all HBV genotypes. The expression of the singly-spliced RNA, as well as that of its...
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