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Article

Stable interdomain interaction within the cytoplasmic domain of CD45 increases enzyme stability.

Biochemical and biophysical research communications - 10 May 2000

Felberg J, Johnson P

Abstract excerpt

CD45 is a leukocyte-specific, two domain transmembrane tyrosine phosphatase. Co-purification of a recombinant protein containing the first phosphatase domain of CD45 (6His-D1) with a recombinant protein containing the second phosphatase domain (GST-D2) from E. coli indicated a stable interaction which resulted in increased stability of the active phosphatase domain present in 6His-D1. This interaction was not...

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Identifiers

PMID: 10799290
DOI: 10.1006/bbrc.2000.2623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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