Article
High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 1998
Metten P, Phillips T J, Crabbe J C, Tarantino L M, McClearn G E, Plomin R, Erwin V G, Belknap J K
Abstract excerpt
C57BL/6J (B6) inbred mice are well known to drink large amounts of alcohol (ethanol) voluntarily and to have only modest ethanol-induced withdrawal under fixed dose conditions. In contrast, DBA/2J (D2) mice are "teetotallers" and exhibit severe ethanol withdrawal. Speculation that an inverse genetic relationship existed between these two traits was substantiated by meta-analysis of existing data collected in...
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