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Article

Saccharomyces cerevisiae mutants defective in heme biosynthesis as a tool for studying the mechanism of phototoxicity of porphyrins.

Photochemistry and photobiology - 1 Dec 1996

Zoładek T, Nguyen B N, Rytka J

Abstract excerpt

Mutants of Saccharomyces cerevisiae accumulating uroporphyrin (UP) or protoporphyrin (PP) were used as a model for the in vivo phototoxic effect of porphyrins observed in the human skin photosensitivity associated with porphyrias (porphyria cutanea tarda and erythropoietic protoporphyria). We hav...

Topics

Mutation
Oxygen
Photosensitizing Agents
Porphyrins
Reactive Oxygen Species
Saccharomyces cerevisiae
Subcellular Fractions

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8972638
DOI: 10.1111/j.1751-1097.1996.tb01861.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8972638-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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