Pink-eyed dilution protein modulates arsenic sensitivity and intracellular glutathione metabolism.

Abstract excerpt

Mutations in the mouse p (pink-eyed dilution) and human P genes lead to melanosomal defects and ocular developmental abnormalities. Despite the critical role played by the p gene product in controlling tyrosinase processing and melanosome biogenesis, its precise biological function is still not defined. We have expressed p heterologously in the yeast Saccharomyces cerevisiae to study its function in greater...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Acid Phosphatase
• Share to Arsenic
• Share to Centrifugation, Density Gradient