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H(2)O(2) generation in Saccharomyces cerevisiae respiratory pet mutants: effect of cytochrome c.

Free radical biology & medicine - 15 Jul 2003

Barros Mario H, Netto Luis E S, Kowaltowski Alicia J

Abstract excerpt

Impaired electron transport chain function has been related to increases in reactive oxygen species (ROS) generation. Here we analyzed different pet mutants of Saccharomyces cerevisiae in order to determine the relative contribution of respiratory chain components in ROS generation and removal. We found that the maintenance of respiration strongly prevented mitochondrial H(2)O(2) release and increased cellular...

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PMID: 12853074
DOI: 10.1016/s0891-5849(03)00307-1

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