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Article

Hem12, an enzyme of heme biosynthesis pathway, is monoubiquitinated by Rsp5 ubiquitin ligase in yeast cells.

Acta biochimica Polonica - 1 Jan 2015

Chelstowska Anna, Jastrzebska Zaneta, Kaminska Joanna, Sadurska Anna, Plochocka Danuta, Rytka Joanna, Zoladek Teresa

Abstract excerpt

Heme biosynthesis pathway is conserved in yeast and humans and hem12 yeast mutants mimic porphyria cutanea tarda (PCT), a hereditary human disease caused by mutations in the UROD gene. Even though mutations in other genes also affect UROD activity and predispose to sporadic PCT, the regulation of UROD is unknown. Here, we used yeast as a model to study regulation of Hem12 by ubiquitination and involvement of Rsp5...

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PMID: 26317124
DOI: 10.18388/abp.2014_776

Genes

UROD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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