The effect of TNF*B gene polymorphism on TNF-alpha and -beta secretion levels in patients with insulin-dependent diabetes mellitus and healthy controls.

doi:10.1111/j.1744-313x.1996.tb00133.x

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Article

The effect of TNF*B gene polymorphism on TNF-alpha and -beta secretion levels in patients with insulin-dependent diabetes mellitus and healthy controls.

European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Dec 1996

Whichelow C E, Hitman G A, Raafat I, Bottazzo G F, Sachs J A

Abstract excerpt

TNF-alpha and -beta have been implicated in the development of HLA-associated autoimmune diseases. It has been suggested that inter-individual differences in the secretion levels of these cytokines may contribute to the predisposition of certain individuals to the development of diseases such as...

Topics

Cells, Cultured
Diabetes Mellitus, Type 1
Genotype
HLA-B Antigens
HLA-DR Antigens
Haplotypes
Humans
Leukocytes, Mononuclear
Lymphotoxin-alpha
Polymorphism, Genetic
Tumor Necrosis Factor-alpha

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Open in PubMed

Identifiers

PMID: 8971540
DOI: 10.1111/j.1744-313x.1996.tb00133.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8971540-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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