Article
[Induction by benz(a)pyrene of squamous cell metaplasia of the respiratory epithelium in organ cultures: importance of the route of administration of the carcinogen and genetic susceptibility of the animals].
Arkhiv patologii - 1 Jan 2000
Kolesnichenko T S, Gor'kova T G
Abstract excerpt
A comparative study was made of transplacental (in vivo) and direct (in vitro) effects of benz(a)pyrene (BP) in the organ cultures of embryonal lungs of mouse susceptible (strain A) and resistant (C57 Bl) to pulmonary blastomogenesis. The development of the epithelium squamous cell metaplasia was...
Topics
- Animals
- Benzo(a)pyrene
- Carcinogens
- Dose-Response Relationship, Drug
- Epithelium
- Female
- Genetic Predisposition to Disease
- Lung Neoplasms
- Maternal-Fetal Exchange
- Metaplasia
- Mice
- Mice, Inbred A
- Mice, Inbred C57BL
- Organ Culture Techniques
- Pregnancy
- Pulmonary Blastoma