[Induction by benz(a)pyrene of squamous cell metaplasia of the respiratory epithelium in organ cultures: importance of the route of administration of the carcinogen and genetic susceptibility of the animals].

Abstract excerpt

A comparative study was made of transplacental (in vivo) and direct (in vitro) effects of benz(a)pyrene (BP) in the organ cultures of embryonal lungs of mouse susceptible (strain A) and resistant (C57 Bl) to pulmonary blastomogenesis. The development of the epithelium squamous cell metaplasia was observed only after direct application of BP on the lung explants in vitro. Correlation between metaplasia frequency...

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