Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic approaches to the function of insulin-like growth factor-binding proteins during rodent development.

Hormone research - 1 Jan 1996

Pintar J E, Cerro J A, Wood T L

Abstract excerpt

Gene targeting provides a direct method for introducing mutations into specific mouse loci. This approach has been used productively to demonstrate that insulin-like growth factor (IGF) peptides and receptors are required for normal prenatal growth. Six genes comprising a third major component of the IGF system, the IGF-binding proteins (IGFBPs), are all expressed during prenatal rodent development. One of these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Fetus
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Techniques

Share to Multigene Family

Share to Mutation

Share to Pregnancy

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 8964578
DOI: 10.1159/000184782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic approaches to the function of insulin-like growth factor-binding proteins during rodent development.PMID 8964578Read ↗

Selective Alterations in Organ Sizes in Mice with a Targeted Disruption of the Insulin-Like Growth Factor Binding Protein-2 GeneSemantic proximity Read ↗

Gene-targeting and transgenic approaches to IGF and IGF binding protein functionSemantic proximity Read ↗

Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.Semantic proximity Read ↗

Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels.Semantic proximity Read ↗

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.Semantic proximity Read ↗

Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins.Semantic proximity Read ↗

A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit.Semantic proximity Read ↗

Inactivation of the IGF-I gene in mice results in perinatal lethality.Semantic proximity Read ↗

IGF-I is required for normal embryonic growth in mice.Semantic proximity Read ↗

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).Semantic proximity Read ↗

Insulin-Like Growth Factor (IGF) Binding Protein-4 Is Both a Positive and Negative Regulator of IGF Activity in VivoSemantic proximity Read ↗

Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.