Article
The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: screening costs and influence on clinical outcomes in psychiatry.
Clinical pharmacology and therapeutics - 1 Nov 1996
Chen S, Chou W H, Blouin R A, Mao Z, Humphries L L, Meek Q C, Neill J R, Martin W L, Hays L R, Wedlund P J
Abstract excerpt
OBJECTIVES: This study examined factors that affect cost, reliability, and the value of determining the cytochrome P450 2D6 (CYP2D6) polymorphism in clinical practice. STUDY DESIGN: The method of deoxyribonucleic acid isolation, sample preparation, oligonucleotide primers, and polymerase chain reaction procedures were scrutinized for their effect on CYP2D6 genotyping efforts. The determination of the CYP2D6 A, B,...
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