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Article

A cyclophilin function in Hsp90-dependent signal transduction.

Science (New York, N.Y.) - 6 Dec 1996

Duina A A, Chang H C, Marsh J A, Lindquist S, Gaber R F

Abstract excerpt

Cpr6 and Cpr7, the Saccharomyces cerevisiae homologs of cyclophilin-40 (CyP-40), were shown to form complexes with Hsp90, a protein chaperone that functions in several signal transduction pathways. Deletion of CPR7 caused severe growth defects when combined with mutations that decrease the amount of Hsp90 or Sti1, another component of the Hsp90 chaperone machinery. The activities of two heterologous...

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Identifiers

PMID: 8939862
DOI: 10.1126/science.274.5293.1713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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