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Article

In vivo analysis of the Hsp90 cochaperone Sti1 (p60).

Molecular and cellular biology - 1 Jan 1997

Chang H C, Nathan D F, Lindquist S

Abstract excerpt

Hsp90 interacts with Sti1 (p60) in lysates of yeast and vertebrate cells. Here we provide the first analysis of their interaction in vivo. Saccharomyces cerevisiae mutations that eliminate Sti1 or reduce intracellular concentrations of Hsp90 individually have little or no effect on growth at normal temperatures. However, when combined, the mutations greatly reduce or eliminate growth. Furthermore, overexpression...

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Identifiers

PMID: 8972212
DOI: 10.1128/MCB.17.1.318
PMCID: PMC231756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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