<b>Site‐directed mutagenesis of the <i>katG</i> gene of <i>Mycobacterium tuberculosis</i>: effects on catalase–peroxidase activities and isoniazid resistance</b>

Abstract excerpt

Recent studies examining the molecular mechanisms of isoniazid (INH) resistance in Mycobacterium tuberculosis have demonstrated that a significant percentage of drug-resistant strains are mutated in the katG gene which encodes a catalase-peroxidase, and the majority of these alterations are missense mutations which result in the substitution of a single amino acid. In previous reports, residues which may be...

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