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Article

Structure and mapping of spontaneous mutational sites of PyrR from Mycobacterium tuberculosis.

Biochemical and biophysical research communications - 18 Mar 2016

Ghode Pramila, Ramachandran Sarath, Bifani Pablo, Sivaraman J

Abstract excerpt

The emergence of resistant Mycobacterium tuberculosis (Mtb) infection and the dearth of drugs against tuberculosis have made it imperative to identify and validate novel targets and classes of drugs for treatment. The pyrimidine operon regulatory protein (PyrR), a regulator of de novo pyrimidine synthesis, is an essential enzyme and a probable 5-fluorouracil (5-FU) target in Mtb, with mutations in PyrR...

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Identifiers

PMID: 26902118
DOI: 10.1016/j.bbrc.2016.02.071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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