Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genotype-selective phenotypic switch in primary afferent neurons contributes to neuropathic pain.

Pain - 1 Oct 2011

Nitzan-Luques Adi, Devor Marshall, Tal Michael

Abstract excerpt

Pain is normally mediated by nociceptive Aδ and C fibers, while Aβ fibers signal touch. However, after nerve injury, Aβ fibers may signal pain. Using a genetic model, we tested the hypothesis that phenotypic switching in neurotransmitters expressed by Aβ afferents might account for heritable differences in neuropathic pain behavior. The study examined selection-line rats in which one line, high autotomy (HA),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Stem
Share to Ganglia, Spinal
Share to Hyperalgesia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Nerve Fibers, Myelinated

Share to Neuralgia

Share to Neurons, Afferent

Share to Nociceptors

Share to Rats, Wistar

Source

Identifiers

PMID: 21872992
DOI: 10.1016/j.pain.2011.07.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genotype-selective phenotypic switch in primary afferent neurons contributes to neuropathic pain.PMID 21872992Read ↗

Dynamic genotype-selective "phenotypic switching" of CGRP expression contributes to differential neuropathic pain phenotype.Semantic proximity Read ↗

Hyperexcitability in sensory neurons of rats selected for high versus low neuropathic pain phenotype.Semantic proximity Read ↗

Unity vs. diversity of neuropathic pain mechanisms: Allodynia and hyperalgesia in rats selected for heritable predisposition to spontaneous pain.Semantic proximity Read ↗

Deconstructing the neuropathic pain phenotype to reveal neural mechanisms.Semantic proximity Read ↗

Coupling gene chip analyses and rat genetic variances in identifying potential target genes that may contribute to neuropathic allodynia development.Semantic proximity Read ↗

Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons.Semantic proximity Read ↗

Variability in C-type lectin receptors regulates neuropathic pain-like behavior after peripheral nerve injury.Semantic proximity Read ↗

Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms.Semantic proximity Read ↗

Expression of DRG candidate pain molecules after nerve injury--a comparative study among five inbred mouse strains with contrasting pain phenotypes.Semantic proximity Read ↗

[Genetics of neuropathic pain].Semantic proximity Read ↗

Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice.Semantic proximity Read ↗

Autotomy behavior correlates with the DRG and spinal expression of sodium channels in inbred mouse strains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.