Article
Neuraxial Cytokines in Pain States.
Frontiers in immunology - 1 Jan 2019
Gonçalves Dos Santos Gilson, Delay Lauriane, Yaksh Tony L, Corr Maripat
Abstract excerpt
A high-intensity potentially tissue-injuring stimulus generates a homotopic response to escape the stimulus and is associated with an affective phenotype considered to represent pain. In the face of tissue or nerve injury, the afferent encoding systems display robust changes in the input-output function, leading to an ongoing sensation reported as painful and sensitization of the nociceptors such that an enhanced...
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