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Article

Quantitative Analysis of the Packaging Capacity of Recombinant Adeno-Associated Virus

10 Nov 1996

Abstract excerpt

Recombinant adeno-associated viruses (AAV) are among the most promising vectors for gene therapy of genetic diseases, including cystic fibrosis (CF). However, because of its small genome size, the capacity of AAV to package a therapeutic gene is limited. The efficiency of packaging the cystic fibrosis transmembrane conductance Regulator (CFTR) gene into AAV will be an important factor in determining whether...

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PMID: 8934224
DOI: 10.1089/hum.1996.7.17-2101

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