Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expanding AAV Packaging Capacity with Trans-splicing or Overlapping Vectors: A Quantitative Comparison

1 Oct 2001

Abstract excerpt

Recombinant adeno-associated (rAAV) viral vectors hold great therapeutic potential for human diseases. However, a relatively small packaging capacity (less than 5 kb) has limited the application of rAAV for certain diseases such as cystic fibrosis and Duchenne muscular dystrophy. Here we compared two mechanistically distinct approaches to overcome packaging restraints with rAAV vectors. The trans-splicing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA Interference and Gene Delivery
Share to Viral gastroenteritis research and epidemiology
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11592843
DOI: 10.1006/mthe.2001.0456

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expanding AAV Packaging Capacity with Trans-splicing or Overlapping Vectors: A Quantitative ComparisonPMID 11592843Read ↗

Effective delivery of large genes to the retina by dual AAV vectors.Semantic proximity Read ↗

Production and Discovery of Novel Recombinant Adeno‐Associated Viral VectorsSemantic proximity Read ↗

Extending AAV Packaging Cargo through Dual Co-Transduction: Efficient Protein Trans-Splicing at Low Vector DosesSemantic proximity Read ↗

Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors.Semantic proximity Read ↗

Hybrid Adeno-Associated Virus Bearing Nonhomologous Inverted Terminal Repeats Enhances Dual-Vector Reconstruction of Minigenes <i>In Vivo</i>Semantic proximity Read ↗

mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapySemantic proximity Read ↗

Trans-Splicing Adeno-Associated Viral Vector-Mediated Gene Therapy Is Limited by the Accumulation of Spliced mRNA but Not by Dual Vector Coinfection EfficiencySemantic proximity Read ↗

Producing high-quantity and high-quality recombinant adeno-associated virus by low-cis triple transfectionSemantic proximity Read ↗

Size does matter: overcoming the adeno-associated virus packaging limitSemantic proximity Read ↗

Expression of Human Factor VIII by Splicing between Dimerized AAV VectorsSemantic proximity Read ↗

Polycistronic Viral VectorsSemantic proximity Read ↗

Production and Application of Multicistronic Constructs for Various Human Disease TherapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.