Demonstration of slow acetylator genotype of N-acetyltransferase in isoniazid neuropathy using an archival hematoxylin and eosin section of a sural nerve biopsy specimen.

doi:10.1016/0022-510x(95)00254-y

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Article

Demonstration of slow acetylator genotype of N-acetyltransferase in isoniazid neuropathy using an archival hematoxylin and eosin section of a sural nerve biopsy specimen.

Journal of the neurological sciences - 1 Jan 1996

Yamamoto M, Sobue G, Mukoyama M, Matsuoka Y, Mitsuma T

Abstract excerpt

The genotype for N-acetyltransferase was analyzed in five Japanese patients with isoniazid neuropathy by using the allele specific polymerase chain reaction for a single slice of the 30-year-old paraffin-embedded and hematoxylin-eosin stained sural nerve biopsy specimens. We found slow acetylator...

Topics

Acetylation
Alleles
Antitubercular Agents
Arylamine N-Acetyltransferase
Base Sequence
Biopsy
DNA Primers
Eosine Yellowish-(YS)
Genotype
Hematoxylin
Humans
Isoniazid
Mutation
Paraffin Embedding
Peripheral Nervous System Diseases
Polymerase Chain Reaction
Sural Nerve
Time Factors

Source

Open in PubMed

Identifiers

PMID: 8926496
DOI: 10.1016/0022-510x(95)00254-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8926496-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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