Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor.

1 Nov 1996

Abstract excerpt

The homeodomain protein PDX-1, referred as IPF-1/STF-1/IDX-1, is a transcriptional factor that plays a critical role in the control of several genes expressed in the pancreatic islet. PDX-1 gene expression has been previously shown to be reduced in cultured beta-cell lines chronically exposed to high glucose concentrations. As the glucose transporter type 2 (GLUT2) gene expression is selectively decreased in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetics and Neurodevelopmental Disorders
Share to Metabolism, Diabetes, and Cancer
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8923459
DOI: 10.1210/mend.10.11.8923459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor.PMID 8923459Read ↗

Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cellsSemantic proximity Read ↗

Involvement of PDX-1 in activation of human insulin gene transcriptionSemantic proximity Read ↗

Involvement of the Homeodomain-Containing Transcription Factor PDX-1 in Islet Amyloid Polypeptide Gene TranscriptionSemantic proximity Read ↗

Functional expression and analysis of the pancreatic transcription factor PDX-1 in yeast.Semantic proximity Read ↗

The PDX-1 activation domain provides specific functions necessary for transcriptional stimulation in pancreatic beta-cells.Semantic proximity Read ↗

The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 CellsSemantic proximity Read ↗

Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1.Semantic proximity Read ↗

Functional Conservation of Regulatory Elements in the pdx-1 Gene: PDX-1 and Hepatocyte Nuclear Factor 3β Transcription Factors Mediate β-Cell-Specific ExpressionSemantic proximity Read ↗

Identification of cis- and trans-Active Factors Regulating Human Islet Amyloid Polypeptide Gene Expression in Pancreatic β-CellsSemantic proximity Read ↗

Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.Semantic proximity Read ↗

Regulation of the human GLUT4 gene promoter: Interaction between a transcriptional activator and myocyte enhancer factor 2ASemantic proximity Read ↗

Regulation of pdx-1 Gene ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.