Article
Immortalization of human lymphocytes by Epstein-Barr virus.
The Yale journal of biology and medicine - 1 Jan 2000
Miller G
Abstract excerpt
Epstein-Barr virus (EBV) confers upon normal lymphocytes derived from bone marrow the ability to proliferate indefinitely in a test tube. This process, called immortalization, is crucial to the pathogenesis of EBV infections. Inside the immortalized lymphocyte the EBV genome exists as a complete...
Topics
- Antigens, Viral
- B-Lymphocytes
- Cell Line
- Cell Nucleus
- Cell Transformation, Neoplastic
- Cell Transformation, Viral
- DNA
- DNA, Viral
- Genes, Viral
- Herpesvirus 4, Human
- Humans
- Mutation