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Article

Immortalization of human lymphocytes by Epstein-Barr virus.

The Yale journal of biology and medicine - 1 Jan 2000

Miller G

Abstract excerpt

Epstein-Barr virus (EBV) confers upon normal lymphocytes derived from bone marrow the ability to proliferate indefinitely in a test tube. This process, called immortalization, is crucial to the pathogenesis of EBV infections. Inside the immortalized lymphocyte the EBV genome exists as a complete multicopy circular plasmid which is probably not integrated into the cell chromosome. Most of the viral genetic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 6295007
PMCID: PMC2596471

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