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Article

Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting.

Gene - 31 Oct 1996

Toth L R, Smith T J, Jones C, de Silva H V, Smithies O, Maeda N

Abstract excerpt

'In-out' gene targeting using a hypoxanthine phosphoribosyltransferase (HPRT) minigene was applied to generate two new alleles in the gene (Apob) coding for apolipoprotein B (apo B) in murine embryonic stem (ES) cells. Homologous integration of the targeting vector during the 'in step' disrupted the Apob gene leading to an allele encoding apo B81, having a 19% carboxyl-terminal truncation. All six targeted cells...

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Identifiers

PMID: 8921909
DOI: 10.1016/0378-1119(96)00360-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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