Genetic control of local mutation rates.

doi:10.1073/pnas.2625619123

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Article

Genetic control of local mutation rates.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2026

Caballero Madison, Koren Amnon

Abstract excerpt

Mutations are the source of evolutionary novelty but also the cause of genetic diseases and cancer. Mutation rates are known to be heterogeneous along the genome, however the extent to which local mutation rates vary among individuals in a population and are genetically determined is unknown. To test this, we analyzed the chromosomal distribution of somatic mutations in cell lines from 1,662 individuals,...

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Share to Genome, Human
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Identifiers

PMID: 42658760
DOI: 10.1073/pnas.2625619123
PMCID: PMC13534546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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