Article
Identification of novel exon-deleted progesterone receptor variant mRNAs in human breast tissue.
Biochemical and biophysical research communications - 1 Nov 1996
Leygue E, Dotzlaw H, Watson P H, Murphy L C
Abstract excerpt
Using an approach based on the co-amplification of wild-type and exon deleted progesterone receptor (PR) variant cDNAs, we identified exon-deleted PR variant mRNAs in both normal and neoplastic human breast tissues. Several naturally occurring variants, whose sequences revealed precise whole exon deletions, may encode putative PR-like proteins which lack some functional domains of the wild-type PR molecule. We...
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