Identification of novel exon-deleted progesterone receptor variant mRNAs in human breast tissue.

doi:10.1006/bbrc.1996.1616

Back to search

Article

Identification of novel exon-deleted progesterone receptor variant mRNAs in human breast tissue.

Biochemical and biophysical research communications - 1 Nov 1996

Leygue E, Dotzlaw H, Watson P H, Murphy L C

Abstract excerpt

Using an approach based on the co-amplification of wild-type and exon deleted progesterone receptor (PR) variant cDNAs, we identified exon-deleted PR variant mRNAs in both normal and neoplastic human breast tissues. Several naturally occurring variants, whose sequences revealed precise whole exon...

Topics

Breast
Breast Neoplasms
Carcinoma, Ductal, Breast
Exons
Female
Genetic Variation
Humans
Polymerase Chain Reaction
RNA, Messenger
Receptors, Estrogen
Receptors, Progesterone
Sequence Deletion
Tumor Cells, Cultured

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.