Article
Androgen-receptor gene structure and function in prostate cancer.
World journal of urology - 1 Jan 1996
Hakimi J M, Rondinelli R H, Schoenberg M P, Barrack E R
Abstract excerpt
Androgen-receptor (AR) gene mutations have been found in clinical prostate cancer, both prior to hormonal therapy and in hormone-refractory disease that persists despite androgen-ablative therapy. Thus, mutations that are present in late-stage disease might arise prior to therapy rather than as a result of therapy. A common feature of mutations in untreated prostate cancer and in hormone-refractory prostate...
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