Article
Androgen receptor in prostate cancer.
Endocrine reviews - 1 Apr 2004
Heinlein Cynthia A, Chang Chawnshang
Abstract excerpt
The normal development and maintenance of the prostate is dependent on androgen acting through the androgen receptor (AR). AR remains important in the development and progression of prostate cancer. AR expression is maintained throughout prostate cancer progression, and the majority of androgen-independent or hormone refractory prostate cancers express AR. Mutation of AR, especially mutations that result in a...
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