Article
The androgen receptor (AR) in syndromes of androgen insensitivity and in prostate cancer.
The Journal of steroid biochemistry and molecular biology - 1 Jan 2000
Avila D M, Zoppi S, McPhaul M J
Abstract excerpt
The actions of androgens, principally testosterone and 5alpha-dihydrotestosterone, are mediated by a specific receptor protein, the androgen receptor (AR), which is encoded by a single-copy gene located on the human X-chromosome. This receptor protein is a prototypical member of the nuclear receptor family and modulates a range of processes during embryogenesis and in the adult. During embryogenesis, normal AR...
Topics
- Androgens
- Humans
- Ligands
- Male
- Mutation
- Neoplasm Metastasis
- Prostatic Neoplasms
- Receptors, Androgen