Article
Physiological coupling of growth factor and steroid receptor signaling pathways: estrogen receptor knockout mice lack estrogen-like response to epidermal growth factor.
Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 1996
Curtis S W, Washburn T, Sewall C, DiAugustine R, Lindzey J, Couse J F, Korach K S
Abstract excerpt
Past studies have shown that epidermal growth factor (EGF) is able to mimic the uterotropic effects of estrogen in the rodent. These studies have suggested a "cross-talk" model in which EGF receptor (EGF-R) signaling results in activation of nuclear estrogen receptor (ER) and its target genes in an estrogen-independent manner. Furthermore, in vitro studies have indicated the requirement for ER in this mechanism....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.