Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration.

Investigative ophthalmology & visual science - 1 Oct 2015

Murray Susan F, Jazayeri Ali, Matthes Michael T, Yasumura Douglas, Yang Haidong, Peralta Raechel, Watt Andy, Freier Sue, Hung Gene, Adamson Peter S, Guo Shuling, Monia Brett P, LaVail Matthew M, McCaleb Michael L

Abstract excerpt

PURPOSE: To preserve photoreceptor cell structure and function in a rodent model of retinitis pigmentosa with P23H rhodopsin by selective inhibition of the mutant rhodopsin allele using a second generation antisense oligonucleotide (ASO). METHODS: Wild-type mice and rats were treated with ASO by intravitreal (IVT) injection and rhodopsin mRNA and protein expression were measured. Transgenic rats expressing the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Electroretinography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macular Degeneration

Share to Oligonucleotides, Antisense

Share to Rats, Transgenic

Share to Real-Time Polymerase Chain Reaction

Share to Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 26436889
DOI: 10.1167/iovs.15-16400
PMCID: PMC5104522

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration.PMID 26436889Read ↗

Preferential silencing of a common dominant rhodopsin mutation does not inhibit retinal degeneration in a transgenic model.Semantic proximity Read ↗

Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme.Semantic proximity Read ↗

Effect of AAV-Mediated Rhodopsin Gene Augmentation on Retinal Degeneration Caused by the Dominant P23H Rhodopsin Mutation in a Knock-In Murine Model.Semantic proximity Read ↗

Knockout and Replacement Gene Surgery to Treat Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa.Semantic proximity Read ↗

Gene augmentation for autosomal dominant retinitis pigmentosa using rhodopsin genomic loci nanoparticles in the P23H+/- knock-in murine model.Semantic proximity Read ↗

Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa.Semantic proximity Read ↗

Correcting a patient-specific Rhodopsin mutation with adenine base editor in a mouse model.Semantic proximity Read ↗

Applications of antisense oligonucleotides for the treatment of inherited retinal diseases.Semantic proximity Read ↗

Antisense oligonucleotide therapy for proline-23-histidine autosomal dominant retinitis pigmentosa.Semantic proximity Read ↗

Adeno-Associated Virus-Mediated Rhodopsin Replacement Provides Therapeutic Benefit in Mice with a Targeted Disruption of the Rhodopsin GeneSemantic proximity Read ↗

Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten diseaseSemantic proximity Read ↗

Genotypic and phenotypic characterization of P23H line 1 rat model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.