Article
Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans.
Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 1995
Rothman N, Haas R, Hayes R B, Li G L, Wiemels J, Campleman S, Quintana P J, Xi L J, Dosemeci M, Titenko-Holland N
Abstract excerpt
Occupational exposure to benzene is known to cause leukemia, but the mechanism remains unclear. Unlike most other carcinogens, benzene and its metabolites are weakly or nonmutagenic in most simple gene mutation assays. Benzene and its metabolites do, however, produce chromosomal damage in a varie...
Topics
- Adolescent
- Adult
- Benzene
- Bone Marrow
- Case-Control Studies
- Female
- Genetic Carrier Screening
- Genetic Variation
- Glycophorins
- Hematopoietic Stem Cells
- Humans
- Lymphocyte Count
- Male
- Middle Aged