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Article

Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans.

Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 1995

Rothman N, Haas R, Hayes R B, Li G L, Wiemels J, Campleman S, Quintana P J, Xi L J, Dosemeci M, Titenko-Holland N

Abstract excerpt

Occupational exposure to benzene is known to cause leukemia, but the mechanism remains unclear. Unlike most other carcinogens, benzene and its metabolites are weakly or nonmutagenic in most simple gene mutation assays. Benzene and its metabolites do, however, produce chromosomal damage in a variety of systems. Here, we have used the glycophorin A (GPA) gene loss mutation assay to evaluate the nature of DNA damage...

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Identifiers

PMID: 7732033
DOI: 10.1073/pnas.92.9.4069
PMCID: PMC42104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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