Article
Altered spontaneous discharge rate and pattern of basal ganglia output neurons in the circling (ci2) rat mutant.
Neuroscience - 1 Jan 2003
Fedrowitz M, Lindemann S, Löscher W, Gernert M
Abstract excerpt
The circling rat is an autosomal recessive mutant (homozygous ci2/ci2) characterized by lateralized rotational behavior, locomotor hyperactivity, ataxia, stereotypic head movements, and deafness. Previous neurochemical investigations showed that ci2 rats of both genders have a lower tissue content of dopamine in the striatum ipsilateral to the preferred direction of circling. For further evaluation as to whether...
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