Article
Asymmetric elevation of striatal dopamine D2 receptors in the chakragati mouse: neurobehavioral dysfunction in a transgenic insertional mutant.
Brain research - 15 May 1992
Fitzgerald L W, Miller K J, Ratty A K, Glick S D, Teitler M, Gross K W
Abstract excerpt
We have previously reported the discovery of a transgenic insertional mutant, recently named the chakragati (ckr) mouse, which displays lateralized circling, locomotor hyperactivity, hyperreactivity, as well as body weight deficits. Since lateralized dopamine function is associated with circling behavior we sought to determine whether dopamine (DA) D1 and D2 receptors were asymmetrically distributed in the...
Topics
- Animals
- Brain
- Corpus Striatum
- Dopamine Agents
- Ergolines
- Limbic System
- Mice
- Mice, Neurologic Mutants
- Mice, Transgenic
- Mutagenesis, Insertional
- Nerve Tissue Proteins