Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic epidemiology of early onset breast cancer.

Journal of medical genetics - 1 Dec 1994

Eccles D, Marlow A, Royle G, Collins A, Morton N E

Abstract excerpt

Risks for breast cancer when there is a family history of the disease are usually calculated using data from segregation analyses which favour a single dominant gene with high penetrance. There are, however, at least three loci known to be associated with familial breast cancer (p53, BRCA1, and an as yet unpublished locus) and the frequencies and penetrances of these genes are not likely to be the same. We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Breast Neoplasms
Share to Age of Onset

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to BRCA1 gene

Share to Genotype

Share to Pedigree

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 7891376
DOI: 10.1136/jmg.31.12.944
PMCID: PMC1016695

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic epidemiology of early onset breast cancer.PMID 7891376Read ↗

Autosomal dominant inheritance of early-onset breast cancer. Implications for risk prediction.Semantic proximity Read ↗

Segregation analysis of breast cancer: a comparison of type-dependent age-at-onset versus type-dependent susceptibility models.Semantic proximity Read ↗

Familial risk of early and late onset cancer.Semantic proximity Read ↗

Segregation analysis of breast cancer in a population-based sample of postmenopausal probands: The Iowa Women's Health Study.Semantic proximity Read ↗

Inclusion of risk factor covariates in a segregation analysis of a population-based sample of 426 breast cancer families.Semantic proximity Read ↗

BRCA mutations, molecular markers, and clinical variables in early-onset breast cancer: a population-based study.Semantic proximity Read ↗

A simple method for co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example.Semantic proximity Read ↗

A family-based, genome-wide association study of young-onset breast cancer: inherited variants and maternally mediated effects.Semantic proximity Read ↗

Prediction of genetic risks from segregation analyses of morbid risks.Semantic proximity Read ↗

The BOADICEA model of genetic susceptibility to breast and ovarian cancer.Semantic proximity Read ↗

Why are the majority of hereditary cases of early-onset breast cancer sporadic? A simulation study.Semantic proximity Read ↗

Identification of inherited genetic variations influencing prognosis in early-onset breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.