Ti-6Al-4V ion solution inhibition of osteogenic cell phenotype as a function of differentiation timecourse in vitro.

doi:10.1016/0142-9612(96)00009-9

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Article

Ti-6Al-4V ion solution inhibition of osteogenic cell phenotype as a function of differentiation timecourse in vitro.

Biomaterials - 1 Oct 1996

Thompson G J, Puleo D A

Abstract excerpt

Metal ions released from the implant surface are suspected of playing some contributing role in loosening of hip and knee prostheses. previous work in this laboratory demonstrated that sublethal doses of the ionic constituents of Ti-6Al-4V alloy suppressed expression of the osteoblastic phenotype...

Topics

Alkaline Phosphatase
Alloys
Aluminum
Analysis of Variance
Animals
Bone Marrow
Bone Marrow Cells
Calcium
Cell Differentiation
Cells, Cultured
Osteocalcin
Phenotype
Prostheses and Implants
Proteins
Rats
Stromal Cells
Titanium
Vanadium

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