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Article

Ti-6Al-4V ion solution inhibition of osteogenic cell phenotype as a function of differentiation timecourse in vitro.

Biomaterials - 1 Oct 1996

Thompson G J, Puleo D A

Abstract excerpt

Metal ions released from the implant surface are suspected of playing some contributing role in loosening of hip and knee prostheses. previous work in this laboratory demonstrated that sublethal doses of the ionic constituents of Ti-6Al-4V alloy suppressed expression of the osteoblastic phenotype and deposition of a mineralized matrix. The purpose of this work was to further explore this suppression as a function...

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Identifiers

PMID: 8894086
DOI: 10.1016/0142-9612(96)00009-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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