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Article

Structure-based thermodynamic scale of alpha-helix propensities in amino acids.

Biochemistry - 22 Oct 1996

Luque I, Mayorga O L, Freire E

Abstract excerpt

A structural parameterization of the folding energetics has been used to predict the effect of single amino acid mutations at exposed locations in alpha-helices. The results have been used to derive a structure-based thermodynamic scale of alpha-helix propensities for amino acids. The structure-based thermodynamic analysis was performed for four different systems for which structural and experimental...

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PMID: 8885848
DOI: 10.1021/bi961319s

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