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Article

Importance of individual side chains for the stability of a protein fold: computational alanine scanning of the insulin monomer.

Journal of computational chemistry - 30 Nov 2006

Zoete Vincent, Meuwly Markus

Abstract excerpt

A new computational approach is proposed to probe the importance of residue side chains for the stability of a protein fold. Computational mutations to estimate protein stability (CMEPS) is based on the notion that the binding free energy corresponding to the complexation of a given side chain, considered as a "pseudo-ligand" of the wild type protein, reflects the importance of this side chain to the...

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Identifiers

PMID: 16981237
DOI: 10.1002/jcc.20512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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