Article
A new type of congenital dysfibrinogen, fibrinogen Bremen, with an A alpha Gly-17 to Val substitution associated with hemorrhagic diathesis and delayed wound healing.
Thrombosis and haemostasis - 1 Sept 1993
Wada Y, Niwa K, Maekawa H, Asakura S, Sugo T, Nakanishi M, Auerswald G, Popp M, Matsuda M
Abstract excerpt
We have identified a new type of A alpha Gly-17 to Val substitution in a congenital dysfibrinogen, fibrinogen Bremen, derived from a 15-year-old boy having manifested easy bruising and delayed wound healing. The functional abnormality was characterized by altered fibrin monomer polymerization, wh...
Topics
- Adolescent
- Amino Acid Sequence
- Biopolymers
- Fibrinogens, Abnormal
- Glycine
- Hemorrhagic Disorders
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Time Factors
- Valine
- Wound Healing