Proline isomerism in staphylococcal nuclease characterized by NMR and site-directed mutagenesis.

doi:10.1038/329266a0

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Article

Proline isomerism in staphylococcal nuclease characterized by NMR and site-directed mutagenesis.

Nature - 1 Jan 2000

Evans P A, Dobson C M, Kautz R A, Hatfull G, Fox R O

Abstract excerpt

Nuclear magnetic resonance (NMR) studies have shown that two distinct folded conformations of staphylococcal nuclease coexist in solution and that these two states can interconvert directly without passing through an unfolded state. These experiments have also revealed that the two forms have ver...

Topics

Isomerism
Magnetic Resonance Spectroscopy
Micrococcal Nuclease
Mutation
Proline
Protein Conformation

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