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Article

Proline isomerism in staphylococcal nuclease characterized by NMR and site-directed mutagenesis.

Nature - 1 Jan 2000

Evans P A, Dobson C M, Kautz R A, Hatfull G, Fox R O

Abstract excerpt

Nuclear magnetic resonance (NMR) studies have shown that two distinct folded conformations of staphylococcal nuclease coexist in solution and that these two states can interconvert directly without passing through an unfolded state. These experiments have also revealed that the two forms have very different folding kinetics, although the possibility that one component is an obligatory intermediate for the folding...

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PMID: 3627269
DOI: 10.1038/329266a0

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