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Article

Substitution of two variant residues in the protein tyrosine phosphatase-like PTP35/IA-2 sequence reconstitutes catalytic activity.

Biochemical and biophysical research communications - 14 Oct 1996

Magistrelli G, Toma S, Isacchi A

Abstract excerpt

The PTP35/IA-2 protein shows high homology to protein tyrosine phosphatases (PTPases) but harbours a few changes in invariant PTPase residues. Accordingly, PTP35/IA-2 has been reported to lack catalytic activity in vitro, and its in vivo biological function remains to be determined. We investigated if reversion of selected amino acids to the PTPase consensus could reconstitute enzymatic activity. Substitution of...

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Identifiers

PMID: 8878556
DOI: 10.1006/bbrc.1996.1549

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