Article
Type 1 multiple endocrine neoplasia (MEN1): contribution of genetic analysis to the screening and follow-up of a large French kindred.
Clinical endocrinology - 1 Jul 1999
Waterlot C, Porchet N, Bauters C, Decoulx M, Wémeau J L, Proye C, Degand P M, Aubert J P, Cortet C, Dewailly D
Abstract excerpt
OBJECTIVE: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal genetic disorder, the clinical phenotype of which includes tumours of the parathyroids and/or anterior pituitary and/or endocrine pancreas. The genetic defect has been mapped to the chromosome 11q13 and the MEN1 gene has been recently identified, thus allowing genetic screening in affected kindreds. The aim of this study was to establish the...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Testing
- Heterozygote
- Humans
- Male