Article
Human mitochondrial complex I dysfunction.
Biochimica et biophysica acta - 17 Jul 1992
Cooper J M, Mann V M, Krige D, Schapira A H
Abstract excerpt
In humans, complex I dysfunction has been observed in a high percentage of patients with mitochondrial myopathy. Analysis of mitochondria from these patients suggests the function and assembly of complex I is particularly susceptible to abnormalities of mitochondrial DNA, involving either point mutations of tRNA genes or major deletions. The evidence for a complex I defect in Parkinson's disease is accumulating,...
Topics
- Aging
- Brain Diseases
- Chromosome Deletion
- DNA, Mitochondrial
- Humans
- Metabolic Diseases
- Mitochondria
- Muscular Diseases
- Mutation
- NAD(P)H Dehydrogenase (Quinone)
- Parkinson Disease