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Article

Human mitochondrial complex I dysfunction.

Biochimica et biophysica acta - 17 Jul 1992

Cooper J M, Mann V M, Krige D, Schapira A H

Abstract excerpt

In humans, complex I dysfunction has been observed in a high percentage of patients with mitochondrial myopathy. Analysis of mitochondria from these patients suggests the function and assembly of complex I is particularly susceptible to abnormalities of mitochondrial DNA, involving either point mutations of tRNA genes or major deletions. The evidence for a complex I defect in Parkinson's disease is accumulating,...

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PMID: 1633185
DOI: 10.1016/s0005-2728(05)80019-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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