Article
Regulation of protein tyrosine phosphatase 1C: opposing effects of the two src homology 2 domains.
Protein engineering - 1 Dec 1995
Pregel M J, Shen S H, Storer A C
Abstract excerpt
The regulatory roles of the two src homology 2 (SH2) domains of protein tyrosine phosphatase 1C were investigated by comparing recombinant full-length PTP1C with mutants in which either the N-terminal SH2 (N-SH2) domain (PTP1C delta NSH2), the C-terminal SH2 (C-SH2) domain (PTP1C delta CSH2) or both SH2 domains were deleted (PTP1C delta NSH2 delta CSH2). This revealed that the SH2 domains have opposing and...
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