Article
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
The Journal of biological chemistry - 6 May 1994
Sugimoto S, Wandless T J, Shoelson S E, Neel B G, Walsh C T
Abstract excerpt
The cytoplasmic insulin receptor substrate-1 (IRS-1), which is multiply phosphorylated in vivo on tyrosine residues, is a known binding protein for the tandem src homology 2 (SH2) domain-containing protein tyrosine phosphatase, SH-PTP2. Eleven phosphotyrosyl (pY) peptides from IRS-1 were screened...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Catalysis
- Enzyme Activation
- Humans
- Insulin Receptor Substrate Proteins
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Peptide Fragments
- Phosphoproteins
- Phosphorylation
- Phosphotyrosine