Chrousos syndrome: a seminal report, a phylogenetic enigma and the clinical implications of glucocorticoid signalling changes.

Abstract excerpt

BACKGROUND: Glucocorticoids regulate a broad spectrum of physiologic functions and play important roles in resting and stress homeostasis. Their actions are mediated by the nuclear glucocorticoid receptor (GR). DESIGN: Using a patient as a stimulus, we reviewed briefly the area of Primary General...

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