Article
Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder.
The Journal of clinical endocrinology and metabolism - 1 May 2008
Charmandari Evangelia, Kino Tomoshige, Ichijo Takamasa, Chrousos George P
Abstract excerpt
CONTEXT: Primary generalized glucocorticoid resistance is a rare genetic condition characterized by generalized, partial, target-tissue insensitivity to glucocorticoids. We review the clinical aspects, molecular mechanisms, and implications of this disorder. EVIDENCE ACQUISITION: We conducted a systematic review of the published, peer-reviewed medical literature using MEDLINE (1975 through February 2008) to...
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