Article
Antigen-processing polymorphisms in chronic hepatitis C infection.
Experimental and clinical immunogenetics - 1 Jan 1996
Höhler T, Gerken G, Schneider P M, Meyer zum Büschenfelde K H, Rittner C
Abstract excerpt
BACKGROUND: Cytotoxic T cell (CTL) responses may influence the course of a hepatitis C infection. CTL recognize viral peptides on HLA class I molecules. Antigenic peptides for class I presentation are generated by proteasomes and transported into the endoplasmic reticulum by the TAP proteins. It is unknown whether polymorphisms of the antigen-processing genes might influence the development of chronic hepatitis...
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