Article
Genetic variants in antigen presentation-related genes influence susceptibility to hepatitis C virus and viral clearance: a case control study.
BMC infectious diseases - 21 Dec 2014
Huang Peng, Dong Li, Lu Xiaomei, Zhang Yuanyuan, Chen Hongbo, Wang Jie, Zhang Yun, Su Jing, Yu Rongbin
Abstract excerpt
BACKGROUND: Genes related to antigen presentation pathway, which are in the non-classical class-II region of human leukocyte antigen (HLA), play a vital role during the infection of hepatitis C virus (HCV). METHODS: The current study determined the genotypes of 34 tagging-SNPs (single nucleotide polymorphisms) from 9 candidate genes (HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, TAP1, TAP2, LMP2, LMP7, and tapasin) in a...
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