Article
Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection.
Hepatology (Baltimore, Md.) - 1 Sept 2013
Ashraf Shirin, Nitschke Katja, Warshow Usama M, Brooks Collin R, Kim Arthur Y, Lauer Georg M, Hydes Theresa J, Cramp Matthew E, Alexander Graeme, Little Ann-Margaret, Thimme Robert, Neumann-Haefelin Christoph, Khakoo Salim I
Abstract excerpt
UNLABELLED: CD8+ T-cell responses to hepatitis C virus (HCV) are important in generating a successful immune response and spontaneously clearing infection. Human leukocyte antigen (HLA) class I presents viral peptides to CD8+ T cells to permit detection of infected cells, and tapasin is an important component of the peptide loading complex for HLA class I. We sought to determine if tapasin polymorphisms affected...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.